The Cleveland Browns are parting ways with defensive tackle Perrion Winfrey ... just hours after a woman claims he threatened her and flashed a gun.

According to local reports, Winfrey is accused of getting into an altercation with a woman at a downtown Cleveland hotel Tuesday night.

The woman -- who claims to know Winfrey -- said she and a friend saw the former Oklahoma star in the hotel lobby ... and one of them hurled an insult at him when they were ignored.